Abstract Dual-energy X-ray absorptiometry (DXA) is generally a very useful tool for assessing bone mineral density (BMD) and fracture risk. However, observational studies have shown that in certain instances, BMD as measured by DXA systematically over- or underestimates fracture risk. We herein describe the clinical conundrums encountered when assessing fracture […]
Daily Archives: July 23, 2018
27 posts
Abstract Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due to altered bone properties in diabetes. Circulating biochemical markers of bone turnover have been found to be decreased in type 2 diabetes (T2D) and may […]
Abstract The objective of this study was to elucidate micromechanical properties of Biodentine and two experimental calcium silicate cements (CSCs) using Reference Point Indentation (RPI). Biomechanical characteristics of the cement type and the effects of a radiopacifier, liquid components, acid etching treatment and bioactivation in simulated body fluid (SBF) were […]
Abstract Fractures, particularly at the lower extremities and hip, are a complication of diabetes. In both type 1 (T1D) and type 2 diabetes (T2D), fracture risk is disproportionately worse than that predicted from the measurement of bone mineral density. Although an explanation for this discrepancy is the presence of organic […]
Abstract Tissue-level mechanical properties characterize mechanical behavior independently of microscopic porosity. Specifically, quasi-static nanoindentation provides measurements of modulus (stiffness) and hardness (resistance to yielding) of tissue at the length scale of the lamella, while dynamic nanoindentation assesses time-dependent behavior in the form of storage modulus (stiffness), loss modulus (dampening), and […]
Another diagnostic method recently introduced into the human clinical setting to assess bone quality and fracture risk is reference point indentation (RPI). This novel bone indentation technique has been employed in preliminary studies to assess bone tissue mechanical properties in people, and has been shown to correlate with traditional mechanical […]
Abstract Reference Point Indentation (RPI) is a novel microindentation tool that has emerging clinical potential for the assessment of fracture risk as well as use as a laboratory tool for straight-forward mechanical characterisation of bone. Despite increasing use of the tool, little research is available to advise the set-up of […]
Abstract Reference Point Indentation (RPI) has been proposed as a new clinical tool to aid the diagnosis of Osteoporosis. This study has examined the performance of the tool within entire femurs to improve the understanding of the mechanical properties of bone and also to guide future RPI testing to optimize […]
Abstract Substantial evidence shows that skeletal fragility should be considered among the complications associated with type 2 diabetes. Individuals with type 2 diabetes have increased fracture risk, despite normal bone mineral density (BMD) and high BMI-factors that are generally protective against fractures. The mechanisms underlying skeletal fragility in diabetes are […]
Abstract Radiation therapy is widely used in the management of patients with soft tissue sarcoma, genitourinary and gastrointestinal tumors, head and neck tumors, or secondary bone metastasis. Bystander injury to bone in the course of external beam radiation therapy is a prevalent problem associated with considerable morbidity, including the development […]